Methylparaben as a preservative antimicrobial activities will be reduced if there is a nonionic surfactant, such as polysorbate 80, as a result of micelation.
Ammonium Alginate as a humectant incompatible with oxidizing agents and acids and strong bases. Cetrimide in solution can react with metal ions. Cetrimide as surfactants incompatible with soap, anionic surfactant, nonionic surfactant with a high concentration, bentonite, iodine, phenylmercuric nitrate, alkali hydroxide and acid colorant. Acacia as a suspending agent incompatible with some substance like amidopyrine, apomorphine, cresol, ethanol (95%), ferric salts, morphine, phenol, physostigmine, tannins, thymol and vanillin. In formula 1, according to Raymond (2009) Data incompatibility of each ingredient are outlined as follows. Sample analytical incompatibility results EXC-Solformula To know that the results of the analysis features of incompatibility are valid then do a comparison of the output data of each ingredient suspending incompatibility with each other supplemental materials from the e-book edition of the handbook of pharmaceutical excipients 6th edition.
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